A Review on Medicinal Plants with Anti- Arthritis Activity

Author(s):Sakshi G. Tupe, Arshu P. Patel, Trupti B. Kakade

Received: 2024-10-11 Accepted: 2025-01-02 Published: 2025-01-25

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by joint inflammation, leading to pain, stiffness, and functional impairment. Its etiology involves a complex interplay of genetic predispositions and environmental factors, such as smoking and obesity, which trigger inflammatory responses mediated by cytokines like interleukin-1β and interleukin-6. Recent studies emphasize the effectiveness of a "treat-to-target" (T2T) approach in managing RA, aiming for remission or low disease activity through regular monitoring and personalized therapy adjustments. Advances in treatment options, including Janus kinase inhibitors and biologic disease-modifying antirheumatic drugs (DMARDs), have shown promise in controlling disease activity and alleviating symptoms. In addition to conventional therapies, various medicinal plants have demonstrated anti-arthritis properties. Notable examples include Aconitum kusnezoffii (caowu), which contains anti-inflammatory diterpenoid alkaloids; Ligusticum chuanxiong (Chuanxiong Rhizoma), known for its antioxidant effects; and Tripterygiumwilfordii (Thunder God Vine), whose active component triptolide exhibits significant anti-inflammatory activity. Other plants such as Boswellia serrata, recognized for its boswellic acids, and Cinnamomum cassia, which contains therapeutic terpenoids, also show potential benefits. A comprehensive management strategy that integrates both conventional treatments and herbal remedies is essential for improving the quality of life for individuals living with RA.

Keywords: Medicinal Plants, Anti-Arthritis activity, Rheumatoid Arthritis (RA), Psoriatic arthritis

DOI: 10.5281/zenodo.14737118

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